Our research focuses on elucidation of genotype-phenotype relationships using computational and evolutionary genomics approaches. We seek evolutionary interpretation of causal and associated variants underlying genetic disorders and complex traits in humans and animals. We develop computational tools and statistical tests to estimate key parameters of evolutionary processes that shape the sequence and expression variability within and between individuals, populations, and species. We apply theories to genomic diversity and divergence data in order to search for the signatures of selection in the genomes of different organisms. We also study evolutionary innovation, network properties of disease genes, and evolution of gene expression.